The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice
oleh: Wei Zhou, Wen-hui Wu, Zi-lin Si, Hui-ling Liu, Hanyu Wang, Hong Jiang, Ya-fang Liu, Raphael N. Alolga, Cheng Chen, Shi-jia Liu, Xue-yan Bian, Jin-jun Shan, Jing Li, Ning-hua Tan, Zhi-hao Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.