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This article represents a review of the existing literature on possible long-term effects of sport participation at high-level on health. Search of databases was performed through Web of Science and Science Direct including following keywords: metabolic risk factor/syndrome, diabetes mellitus and cardiovascular health. Former athletes tend to adopt healthier lifestyles, which may give them an advantage in relation to risk factors taking into account metabolic risk factor/syndrome, diabetes mellitus and cardiovascular health. Health benefits of physical activities, moreover, depends of engagement at recommended levels, even in subjects who have never been athletes.