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Background: Thyroid dysfunction is the most common occurring endocrine disorder among the general population. According to projections from several readings on thyroid disease, 42 million people in India have been estimated to be suffering from diseases as a result of thyroidism. Yoga has been found valuable in numerous diseases. Yogic exercise restores body roles through the manipulation of cardiovascular, respiratory, and metabolic control mechanism. Yoga has been proven to be an effective adjunct in thyroid conditions in various studies. Objectives: The objective of this study is to assess the effect of yoga on respiratory function, thyroid-stimulating hormone estimation, and hand grip strength as well as quality of life (QoL) in participants with clinically diagnosed thyroid dysfunction. Methods: Twenty-five participants aged between 20 and 50 years were enrolled for the trial. Yoga sessions of four times a week for 3 weeks were given to every subject. Pulmonary function test (PFT), thyroid function, grip strength as well as QoL was measured pre as well as post intervention. Results: Highly significant variations (P < 0.001) were noted within PFT, thyroid function, grip strength as well as QoL parameters Conclusion: Significant effect was found within all the parameters of PFT, thyroid function, hand grip strength as well as QoL following 3 weeks of yoga training.