CCT complex restricts neuropathogenic protein aggregation via autophagy
oleh: Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J. O’Kane, Damian C. Crowther, David C. Rubinsztein
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-12-01 |
Deskripsi
The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavelet al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophagy.