1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity
oleh: Jean Guillon, Solène Savrimoutou, Sandra Rubio, Stéphane Moreau, Noël Pinaud, Mathieu Marchivie, Vanessa Desplat
| Format: | Article |
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| Diterbitkan: | MDPI AG 2020-01-01 |
Deskripsi
1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-<i>a</i>]quinoxaline derivative was achieved by FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).