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Introduction: The emerging and evolving situation of Coronavirus disaese-2019 (COVID-19) threatens the health of all human beings. This study aims to measure the mortality rate and years of life lost (YLL) due to premature death caused by COVID-19 in Iran, Ahvaz Jundishapur University of Medical Sciences. Materials and Methods: In this study, all definite deaths due to COVID-19 were used. First, descriptive analysis, including mean and standard deviation and the number, was performed. Then, raw and age-standardized mortality rates were calculated. The analysis of the number of YLL due to premature death caused by COVID-19 was performed using the YLL template of 2015, from the World Health Organization, in the Excel spreadsheet software version 2007. Results: During the study period (from March 2020 to June 2020), 629 definite deaths due to COVID-19 occurred (men 59.14% and women 40.86%). The mortality rate due to COVID-19 in men and women was 16.24 and 17.17 per 100,000 persons, respectively. The total YLL during the study period was 4,722 (3.06 per thousand persons) in men, 3,691 (2.46 per thousand persons) in women, and 8,413 (2.77 per thousand persons) in both sexes. Conclusion: This study is one of the first studies to measure YLL due to COVID-19 in Iran. The results of this study show that due to the high mortality of this disease, decision-makers should focus on reducing mortality to stop the potential next waves of COVID-19.