Catastrophic disassembly of actin filaments via Mical-mediated oxidation

oleh: Elena E. Grintsevich, Peng Ge, Michael R. Sawaya, Hunkar Gizem Yesilyurt, Jonathan R. Terman, Z. Hong Zhou, Emil Reisler

Format: Article
Diterbitkan: Nature Portfolio 2017-12-01

Deskripsi

MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate.