Synthesis, Crystal Structure and Anti-Leukemic Activity of 1,3-Dihydro-1-{1-[4-(4-phenylpyrrolo[1,2-<i>a</i>]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2<i>H</i>-benzimidazol-2-one
oleh: Jean Guillon, Solène Savrimoutou, Sandra Albenque-Rubio, Noël Pinaud, Stéphane Moreau, Vanessa Desplat
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-02-01 |
Deskripsi
1,3-Dihydro-1-{1-[4-(4-phenylpyrrolo[1,2-<i>a</i>]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2<i>H</i>-benzimidazol-2-one has been synthesized through a multi-step pathway starting from commercially available 2-nitroaniline. A structure characterization of this new substituted pyrrolo[1,2-<i>a</i>]quinoxaline compound was achieved by using FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline derivative shows an interesting cytotoxic potential against several human leukemia cell lines (HL60, K562 and U937 cells).