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In the current scenario of Corona-19 pandemic, absolute awareness among all health – care workers is necessary. History taking and analyzing the symptoms obviously remains the cornerstone for the detection of COVID-19. However,physician must suspect COVID-19 in patients presenting with the chief complaint of gastrointestinal symptoms such as abdominal pain,diarrhea, and vomiting with or without respiratory complaints. This case series conveys an important message about changing our approach in the initial assessment and management of patients with acute abdominal pain or acute on chronic abdominal pain.