Cross-Aldol condensation of isobutyraldehyde and formaldehyde using phase transfer catalyst
oleh: Azhar Hashmi
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2016-09-01 |
Deskripsi
The hydroxypivaldehyde (HPA) precursor intermediate for the synthesis of neopentyl glycol (NPG) is prepared by novel cross Aldol condensation of isobutyraldehyde and formaldehyde at 20 °C using benzyltrimethylammonium hydroxide, a basic phase transfer catalyst. A feed mole ratio of 1.1:1.0:0.04 (isobutyraldehyde:formaldehyde:benzyltrimethylammonium hydroxide) afforded hydroxypivaldehyde as white solid in almost quantitative yield with ∼100% selectivity.