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Ameloblastoma, a benign epithelial odontogenic tumor, is locally aggressive. This tumor comprises about 1% of tumors and cysts arising in the jaws. It appears most commonly in the third to fifth decades and with equal frequency between sexes. They are usually benign in growth pattern but frequently invade locally and occasionally metastasize. Ameloblastoma prevalently occurs in the mandibular molar and the ramus areas. Recurrence frequently appears after inadequate treatment. Therefore, an appropriate diagnosis and treatment planning should be done to prevent the complications and for better prognosis. In this study, a case of plexiform ameloblastoma was presented with its clinical, radiological, histological features, and treatment modalities.