Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A
oleh: Son C. Le, Zhiguang Jia, Jianhan Chen, Huanghe Yang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site.