Insights into the client protein release mechanism of the ATP-independent chaperone Spy
oleh: Wei He, Xinming Li, Hongjuan Xue, Yuanyuan Yang, Jun Mencius, Ling Bai, Jiayin Zhang, Jianhe Xu, Bin Wu, Yi Xue, Shu Quan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
How ATP-independent chaperones release their clients without energy input remains enigmatic. Here the authors discover that chaperone Spy uses its long, disordered N terminus to facilitate client release through competitive, dynamic intramolecular interactions with Spy’s client binding surface.