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<p>Abstract</p> <p>Background</p> <p>To update a cost-effectiveness analysis of rotavirus vaccination in the Netherlands previously published in 2011.</p> <p>Methods</p> <p>The rotavirus burden of disease and the indirect protection of older children and young adults (herd protection) were updated.</p> <p>Results</p> <p>When updated data was used, routine infant rotavirus vaccination in the Netherlands would potentially become an even more cost-effective strategy than previously estimated with the incremental cost per QALY at only €3,000-4,000. Break-even total vaccination costs were indicated at €92–122, depending on the applied threshold.</p> <p>Conclusions</p> <p>We concluded that the results on potentially favourable cost-effectiveness in the previous study remained valid, however, the new data suggested that previous results might represent an underestimation of the economic attractiveness of rotavirus vaccination.</p>