Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura

oleh: Shoko Nakayama, Mitsuhiro Matsuda, Tatsuya Adachi, Sanae Sueda, Kayo Ueda, Kunimitsu Kawahara, Yuka Ohashi, Sumie Awaji, Shigeo Hashimoto, Itaru Matsumura

Format: Article
Diterbitkan: Elsevier 2018-01-01

Deskripsi

A 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. This is the first case report of TNF- and IL-6-producing aggressive HGBL, NOS in the pleura, in which radiological findings mimicked pleural mesothelioma. The aggressive tumor progression in the present case may have been caused by abnormal cytokine production from lymphoma cells.