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Fundus blood vessels are the only terminal blood vessels that observed in the human body. Many diseases have pathological changes in fundus blood vessels. Through the study of these pathological changes, the fundus vascular changes can be used to diagnose diseases. This article summarizes some of the common pathological changes in fundus blood vessels. As well as the common diseases that cause these changes, it is hoped that some diseases can be associated with retinal vascular changes to facilitate the diagnosis of clinical diseases.