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Obesity is characterized by the excessive accumulation of fat, which triggers a low-grade chronic inflammatory process. Currently, the search for compounds with anti-obesogenic effects that help reduce body weight, as well as associated comorbidities, continues. Among this group of compounds are plant extracts and flavonoids with a great diversity of action mechanisms associated with their beneficial effects, such as anti-inflammatory effects and/or as signaling molecules. In the bark of <i>Tabebuia rosea</i> tree, there are different classes of metabolites with anti-inflammatory properties, such as quercetin. Therefore, the present work studied the effect of the ethanolic extract of <i>T. rosea</i> and quercetin on the mRNA of inflammation markers in obesity compared to the drugs currently used. Total RNA was extracted from epididymal adipose tissue of high-fat diet-induced obese Wistar rats treated with orlistat, phentermine, <i>T. rosea</i> extract, and quercetin. The rats treated with <i>T. rosea</i> and quercetin showed 36 and 31% reductions in body weight compared to the obese control, and they likewise inhibited pro-inflammatory molecules: <i>Il6</i>, <i>Il1b</i>, <i>Il18</i>, <i>Lep</i>, <i>Hif1a</i>, and <i>Nfkb1</i> without modifying the expression of <i>Socs1</i> and <i>Socs3</i>. Additionally, only <i>T. rosea</i> overexpressed <i>Lipe</i>. Both <i>T. rosea</i> and quercetin led to a reduction in the expression of pro-inflammatory genes, modifying signaling pathways, which led to the regulation of the obesity-inflammation state.