Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
oleh: Ashley Penvose, Jessica L. Keenan, David Bray, Vijendra Ramlall, Trevor Siggers
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation. Here the authors employ protein-binding microarrays to comprehensively analyze the DNA binding of 12 NR:RXRα heterodimers, and report promiscuous NR-DNA binding.