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<p>The phytochemical screening and antibacterial activity of ethanolic and Methanolic leaves extract of <em>Vernonia amygdalina </em>against five clinical isolates (<em>Staphylococcus aureus, E. coli, Pseudomonas species, Salmonella species and Proteus species</em>) was determined using standard method of analysis. The results of the antibacterial activity of ethanol, methanol and aqueous extract of leaves of <em>V. amygdalina </em>have diameters ranging between 0.4 to 10mm. The plant extracts from the plants had profound activities against gram-positive than gram negative bacteria. From the above studies, it has clearly indicated that <em>V. amygdalina </em>extract may represent new sources of antibacterial drug, if the phytoactive components are purified and proper dosage are determined for administration.</p> <p>International Journal of Environment, Volume-2, Issue-1, Sep-Nov 2013, Pages 147-152</p> <p>DOI: <a href="http://dx.doi.org/10.3126/ije.v2i1.9217">http://dx.doi.org/10.3126/ije.v2i1.9217</a></p>