Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
oleh: Li-Qiu Wang, Tao Liu, Shuai Yang, Lin Sun, Zhi-Yao Zhao, Li-Yue Li, Yuan-Chu She, Yan-Yan Zheng, Xiao-Yan Ye, Qing Bao, Guang-Hui Dong, Chun-Wei Li, Jun Cui
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.