Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Spike-timing prediction in cortical neurons with active dendrites
oleh: Richard eNaud, Brice eBathellier, Wulfram eGerstner
Format: | Article |
---|---|
Diterbitkan: | Frontiers Media S.A. 2014-08-01 |
Deskripsi
A complete single-neuron model must correctly reproduce the firing of spikes and bursts. We present a study of a simplified model of deep pyramidal cells of the cortex with active dendrites. We hypothesized that we can model the soma and its apical tuft with only two compartments, without significant loss in the accuracy of spike-timing predictions. The model is based on experimentally measurable impulse-response functions, which transfer the effect of current injected in one compartment to current reaching the other. Each compartment was modeled with a pair of non-linear differential equations and a small number of parameters that approximate the Hodgkin-and-Huxley equations. The predictive power of this model was tested on electrophysiological experiments where noisy current was injected in both the soma and the apical dendrite simultaneously. We conclude that a simple two-compartment model can predict spike times of pyramidal cells stimulated in the soma and dendrites simultaneously. Our results support that regenerating activity in the dendritic tuft is required to properly account for the dynamics of layer 5 pyramidal cells under in-vivo-like conditions.