Investigation of Cas9 antibodies in the human eye
oleh: Marcus A. Toral, Carsten T. Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G. Bassuk, Matthew H. Porteus, Vinit B. Mahajan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
Pre-existing antibodies against Cas9 proteins represent a potential issue for gene therapies, including those targeting the eye. Here the authors assess the presence of intraocular antibodies, and show that Cas9 antibodies were prevalent in human serum but not the eye, unless prior bacterial infection occurred.