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In order to improve the diagnosis and treatment of bacterial vulvovaginitis (VV) in preschool children with urinary tract diseases, we conducted the prospective controlled study of 86 patients aged 3–6 years, of which: group 1 (n = 21) – VV; group 2 (n = 20) – VV against the background of chronic pyelonephritis with exacerbation; group 3 (n = 20) – VV against the background of acute pyelonephritis; group 4 (n = 25) – VV with dismetabolic nephropathy. Depending on the method of correction, the patients were divided into those that received standard treatment and those that received combined treatment with the use of a bacteriophage complex. It was revealed that chronic forms of VV prevailed in all groups, but when combined with urinary tract diseases (groups 2, 3, 4), the incidence of synechia of the labia minora was significantly increased. It was established that the number of relapses of VV after the combined treatment is significantly lower than after the standard treatment.Inflammatory urogenital diseases in girls are characterized by a high rate of relapse. The combination therapy of VV, including the use of a bacteriophage complex, improves the condition of the vaginal biotope, prevents the persistence of the infection.