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Yung-Wei Chi, Carl J Lavie, Richard V Milani, Christopher J WhiteDepartment of Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USAAbstract: Peripheral arterial disease (PAD) is a major health problem affecting millions of patients worldwide. Many will suffer from intermittent claudication (IC), which leads to marked impairment of quality of life (QoL). Besides surgical and endovascular interventions to improve limb-specific outcomes, pharmacotherapy is an effective tool in the treatment of IC. Cilostazol, a Federal Drug Administration-approved medication for the treatment of IC, has demonstrated consistent efficacy in improving exercise capacity and overall health-related QoL. This manuscript will review the pharmacokinetics, safety, and efficacy of cilostazol in the treatment of patients with IC as well as compare this agent with other proven non-invasive therapies for PAD.Keywords: peripheral arterial disease, cilostazol, intermittent claudication, supervised exercise therapy