Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice
oleh: Liang Yong, Yafen Yu, Bao Li, Huiyao Ge, Qi Zhen, Yiwen Mao, Yanxia Yu, Lu Cao, Ruixue Zhang, Zhuo Li, Yirui Wang, Wencheng Fan, Chang Zhang, Daiyue Wang, Sihan Luo, Yuanming Bai, Shirui Chen, Weiwei Chen, Miao Liu, Jijia Shen, Liangdan Sun
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Calcium/calmodulin-dependent protein kinase IV (CaMK4) has been shown to be involved in autoimmunity but it is not clear how it functions in psoriasis. Here the authors show that CaMK4 is increased in psoriasis and promotes inflammatory responses in mouse models of psoriasis mediated through macrophages and keratinocytes.