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The soft coral genus <i>Sarcophyton</i> contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (<b>1</b>–<b>5</b>) were purified and characterized from an ethyl acetate extract of the red sea soft coral, <i>Sarcophyton convolutum</i>. Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (<b>4</b>) was observed to be active against cell lines A549 and HSC-2 with IC₅₀ values of 49.70 and 53.17 μM, respectively.