Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
oleh: Marc van Oostrum, Benjamin Campbell, Charlotte Seng, Maik Müller, Susanne tom Dieck, Jacqueline Hammer, Patrick G. A. Pedrioli, Csaba Földy, Shiva K. Tyagarajan, Bernd Wollscheid
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surface proteome remodeling largely independent of global proteostasis.