atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure
oleh: Laure Fournier Le Ray, Alexandra Aubry, Wladimir Sougakoff, Matthieu Revest, Jérôme Robert, Isabelle Bonnet, Nicolas Veziris, Florence Morel
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2022-05-01 |
Deskripsi
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.