A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice
oleh: Jie Sun, Ming Wang, Yaqi Zhong, Xuan Ma, Shimin Sun, Chenzhong Xu, Linyuan Peng, Guo Li, Liting Zhang, Zuojun Liu, Ding Ai, Baohua Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Monitoring the aging process in vivo is challenging. Here the authors generate a Glb1 +/m‒Glb1-2A-mCherry (GAC) reporter mouse model, where the GAC signal is consistently correlated with established biomarkers of cellular senescence, cardiac hypertrophy and shortened lifespan, which may prove helpful for studies developing anti-aging interventions.