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Aim: Barbigerone is a natural pyranoisoflavone having antioxidant potential. The current research was aimed to study the anti-diabetic role of barbigerone on streptozotocin-induced experimental rats. Material & methods: To perform the anti-diabetic activity, the animals were segregated into four groups: Group 1- Control (5 ml/kg saline), Group 2- Streptozotocin control (60 mg/kg i.p.), Group 3 and 4 - Barbigerone (10 and 20 mg/kg, respectively). Results: Both the doses showed a beneficial effect on all the parameters assessed. The effect was better pronounced by 20 mg/kg than 10 mg/kg. Barbigerone showed a protective effect on blood glucose, lipid profile, antioxidant, liver enzymes, and inflammatory cytokines. It suggested that barbigerone displayed lipid-lowering action and antiperoxidative effect in streptozotocin-activated diabetic animals. Conclusion: The outcome of this work reflects that 20 mg/kg barbigerone is more potent and produced ameliorative effects in streptozotocin-induced rats.