A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission

oleh: Sabine Bachmaier, Giacomo Giacomelli, Estefanía Calvo-Alvarez, Larissa Rezende Vieira, Jan Van Den Abbeele, Aris Aristodemou, Esben Lorentzen, Matt K. Gould, Ana Brennand, Jean-William Dupuy, Ignasi Forné, Axel Imhof, Marc Bramkamp, Didier Salmon, Brice Rotureau, Michael Boshart

Format: Article
Diterbitkan: Nature Portfolio 2022-09-01

Deskripsi

Trypanosomes can sense signal molecules and coordinate their movement in response to such signals, a phenomenon termed social motility (SoMo). Here, Bachmaier et al show that cyclic AMP response protein 3 (CARP3) localization to the flagellar tip and its interaction with a number of different adenylate cyclases is essential for migration to tsetse fly salivary glands and for SoMo, therewith linking SoMo and cAMP signaling to trypanosome transmission.