Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
oleh: Linh T. Vuong, Carlo Iomini, Sophie Balmer, Davide Esposito, Stuart A. Aaronson, Marek Mlodzik
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliary role.