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Avian, swine and other zoonotic influenza viruses may cause disease with significant impact in both human and animal populations. The Asia Pacific Strategy for Emerging Diseases (APSED), long recognizing the increased global impact of zoonotic diseases on human populations, has been used as the foundation for improving national preparedness and regional coordination for response to zoonotic diseases in the World Health Organization (WHO) Western Pacific Region.1 APSED encourages multisectoral coordination at the human–animal–environment interface as the primary action required for zoonotic disease control.2 In this article we emphasize the effectiveness of these multisectoral collaborations in responding to zoonotic diseases at the regional and country level, using avian influenza as an example.