The CaMKII holoenzyme structure in activation-competent conformations
oleh: Janette B. Myers, Vincent Zaegel, Steven J. Coultrap, Adam P. Miller, K. Ulrich Bayer, Steve L. Reichow
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered linker domain in facilitating cooperative activation.