The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
oleh: Francisco J. Fernández, Jorge Santos-López, Rubén Martínez-Barricarte, Javier Querol-García, Héctor Martín-Merinero, Sergio Navas-Yuste, Martin Savko, William E. Shepard, Santiago Rodríguez de Córdoba, M. Cristina Vega
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Complement activation on foreign cell surfaces leads to the generation of complement opsonins, which activate complement receptor type 3 (CR3) and pathogen clearance by macrophages. Here, the authors reveal structural basis of the interaction between human opsonin iC3b and the von Willebrand A inserted domain of the α chain of CR3.