Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
oleh: Jing-Jing Wang, Fan Liu, Fan Yang, Yi-Zhi Wang, Xin Qi, Ying Li, Qin Hu, Michael X. Zhu, Tian-Le Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto-inhibition has therapeutic potential to prevent acidotoxicity.