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SCC of the prostate is different from other adenocarcinomas in its treatment and prognosis. Here, the patient is a 57-year-old man with benign prostatic hyperplasia that underwent a prostatectomy and, after one month with hematuria and another follow-up radical cystoprostatectomy with lymphadenectomy and urethrectomy. After recovery, the patient experienced radiotherapy and chemotherapy sessions. So, from a review of other literature, we present our case report of squamous cell carcinoma of the prostate that is more aggressive than adenocarcinoma.