Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer
oleh: Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu, Caiyun Zhong
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2021-08-01 |
Deskripsi
Highlights 1. Apatinib suppressed proliferation, induced cell cycle arrest and apoptosis, and inhibited malignancy in NSCLC in vitro and in vivo. 2. Apatinib downregulated PD-L1 and c-Myc in NSCLC through VEGFR2/STAT3 pathway. 3. Apatinib inhibited PD-L1 expression in THP-1 derived macrophages stimulated by the conditioned medium from NSCLC cells and partially restored the activation of Jurkat T cells co-cultured with NSCLC cells. 4. Apatinib induced ROS generation and inhibited Nrf2 and p62 expression, leading to the autophagic and apoptotic cell death in NSCLC.