Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
oleh: Laura Pascual-Reguant, Enrique Blanco, Silvia Galan, François Le Dily, Yasmina Cuartero, Gemma Serra-Bardenys, Valerio Di Carlo, Ane Iturbide, Joan Pau Cebrià-Costa, Lara Nonell, Antonio García de Herreros, Luciano Di Croce, Marc A. Marti-Renom, Sandra Peiró
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating dynamic euchromatin lamina-associated domains (eLADs) during epithelial-to-mesenchymal transition.