Discovery of fungal surface NADases predominantly present in pathogenic species
oleh: Øyvind Strømland, Juha P. Kallio, Annica Pschibul, Renate H. Skoge, Hulda M. Harðardóttir, Lars J. Sverkeli, Thorsten Heinekamp, Olaf Kniemeyer, Marie Migaud, Mikhail V. Makarov, Toni I. Gossmann, Axel A. Brakhage, Mathias Ziegler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Some bacterial pathogens release NADase enzymes into the host cell that deplete the host’s NAD+ pool, thereby causing rapid cell death. Here, Strømland et al. identify NADases on the surface of fungal spores, and show that the enzymes display unique biochemical and structural properties.