Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives
oleh: Abdellatif Mohamed Salaheldin, Mariam Abdullah Al-Sheikh, Hanadi Y. Medrasi
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2013-01-01 |
Deskripsi
Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.