Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples

oleh: Guinevere S. M. Lageveen-Kammeijer, Noortje de Haan, Pablo Mohaupt, Sander Wagt, Mike Filius, Jan Nouta, David Falck, Manfred Wuhrer

Format: Article
Diterbitkan: Nature Portfolio 2019-05-01

Deskripsi

In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in total human plasma.