Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
oleh: Francesca Castoldi, Guido Kroemer, Federico Pietrocola
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2022-12-01 |
Deskripsi
Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.