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This study aimed to test <i>in vitro</i> the antimicrobial activity of 11 essential oils (EOs) against four methicillin-resistant <i>Staphylococcus pseudintermedius</i> (MRSP) and four methicillin-susceptible <i>S. pseudintermedius</i> (MSSP) clinical isolates. The obtained findings demonstrated a clear <i>in vitro</i> efficacy of some tested EOs against both MRSP and MSSP strains. Particularly, modal minimum inhibitory concentration (MIC) values ranging from 1:2048 <i>v</i>/<i>v</i> for <i>Melissa officinalis</i> against an MSSP strain to 1:256 <i>v</i>/<i>v</i> for <i>Cymbopogon</i><i>citratus</i> against all MRSP strains were observed. The best results, highlighting a modal MIC value of 1:1024 <i>v</i>/<i>v</i> for all tested isolates, was provided by <i>Cinnamomum zeylanicum</i>. Intriguingly, <i>Cinnamomum zeylanicum</i> showed, in many cases, a correspondence between minimum bactericidal concentration (MBC) and MIC values, indicating that the inhibiting dose is also often bactericidal. Moreover, a mild antibacterial and bactericidal activity against both MRSP and MSSP isolates was detected for the other tested EOs. Considering the zoonotic potential of <i>S. pseudintermedius</i> and the increased dissemination of multidrug-resistant strains, the employment of EOs could be useful for the treatment of canine pyoderma. Since antibiotic resistance has become the most urgent issue, from the perspective of the One Health initiative, alternative therapeutic approaches are desirable to limit the use of antibiotics or to improve the efficacy of conventional therapies.