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Dental implantation is a popular way to replace natural teeth. Its prognosis is affected by a number of fac⁃ tors including periodontitis. A large number of studies have shown the incidence of peri ⁃implant disease and implant failure rate in periodontal compromised patients are higher than periodontal healthy patients. Peri ⁃implant disease is closely related to the pathogens in periodontitis. What􀆳s more, the long ⁃term success of dental implants is affected by multiple risk factors of periodontitis such as regular oral hygiene maintenance and smoking. This paper reviews the sur⁃ vival rate, the pathogens and the prognosis of implants in periodontal compromised patients.