LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
oleh: Li Zhu, Suresh K. Kandasamy, Susan E. Liao, Ryuya Fukunaga
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target mRNAs such as cyclin A and suppress their translation during Drosophila oogenesis.