Structure of a MacAB-like efflux pump from Streptococcus pneumoniae
oleh: Hong-Bo Yang, Wen-Tao Hou, Meng-Ting Cheng, Yong-Liang Jiang, Yuxing Chen, Cong-Zhao Zhou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
Bacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mechanism.