Pre-Exercise Blood Glucose Levels Determine the Amount of Orally Administered Carbohydrates during Physical Exercise in Individuals with Type 1 Diabetes—A Randomized Cross-Over Trial

oleh: Othmar Moser, Max L. Eckstein, Alexander Mueller, Philipp Birnbaumer, Felix Aberer, Gerd Koehler, Caren Sourij, Harald Kojzar, Peter Pferschy, Pavel Dietz, Richard M. Bracken, Peter Hofmann, Harald Sourij

Format: Article
Diterbitkan: MDPI AG 2019-06-01

Deskripsi

The aim of the study was to assess the amount of orally administered carbohydrates needed to maintain euglycemia during moderate-intensity exercise in individuals with type 1 diabetes. Nine participants with type 1 diabetes (four women, age 32.1 &#177; 9.0 years, BMI 25.5 &#177; 3.9 kg/m<sup>2</sup>, HbA<sub>1c</sub> 55 &#177; 7 mmol/mol (7.2 &#177; 0.6%)) on insulin Degludec were randomized to cycle for 55 min at moderate intensity (63 &#177; 7% VO<sub>2peak</sub>) for five consecutive days on either 75% or 100% of their regular basal insulin dose. The impact of pre-exercise blood glucose concentration on the carbohydrate requirement was analyzed by one-way ANOVA stratified for pre-exercise blood glucose quartiles. The effect of the basal insulin dose on the amount of orally administered carbohydrates was evaluated by Wilcoxon matched-pairs signed-rank test. The amount of orally administered carbohydrates during the continuous exercise sessions was similar for both trial arms (75% or 100% basal insulin) with median [IQR] of 36 g (9&#8722;62 g) and 36 g (9&#8722;66 g) (<i>p</i> = 0.78). The amount of orally administered carbohydrates was determined by pre-exercise blood glucose concentration for both trial arms (<i>p</i> = 0.03). Our study elucidated the importance of pre-exercise glucose concentration related orally administered carbohydrates to maintain euglycemia during exercise in individuals with type 1 diabetes.