Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles
oleh: Eleftherios Karanasios, Simon A. Walker, Hanneke Okkenhaug, Maria Manifava, Eric Hummel, Hans Zimmermann, Qashif Ahmed, Marie-Charlotte Domart, Lucy Collinson, Nicholas T. Ktistakis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
The ULK1 complex is required during autophagosome nucleation, but where autophagic membranes initiate is unknown. Here the authors use super-resolution microscopy to propose that autophagosomes originate from tubulovesicular structures in the ER that align with ATG9 vesicles and recruit ULK1.