Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins
oleh: Allison M. Jones, Petra Virtanen, Disa Hammarlöf, William J. Allen, Ian Collinson, Christopher S. Hayes, David A. Low, Sanna Koskiniemi
| Format: | Article |
|---|---|
| Diterbitkan: | American Society for Microbiology 2021-02-01 |
Deskripsi
Many bacterial species interact via direct cell-to-cell contact using CDI systems, which provide a mechanism to inject toxins that inhibit bacterial growth into one another. Here, we find that two CDI toxins, one that depolarizes membranes and another that degrades RNA, exploit the universally conserved SecY translocon machinery used to export proteins for target cell entry.